Ikibazo cyingirabuzimafatizo: Iyi ndwara ya fungal irashobora gutera indwara ya Alzheimer nkimpinduka mubwonko

(Inzitizi y'amaraso n'ubwonko ， BBB）

Inzitizi y'amaraso n'ubwonko ni bumwe mu buryo bukomeye bwo kwirinda abantu.Igizwe na selile capillary endothelial selile, selile glial selile, na choroide plexus, ituma ubwoko bwihariye bwa molekile ziva mumaraso bwinjira mubwonko bwubwonko ndetse nizindi selile zikikije, kandi burashobora kubuza ibintu bitandukanye byangiza kwinjira mubwonko bwubwonko.Ubwonko, nkigice cyibanga kandi cyingenzi cyumubiri wumuntu, kigenzura imikorere myinshi yingenzi.Inzitizi yubwonko bwamaraso irashobora guhagarika ibintu byangiza mumaraso kandi ikarinda umutekano wubwonko.

Indwara ya Alzheimer ， AD

Indwara ya Alzheimer (AD) ni indwara igenda itera indwara ya neurodegenerative itangirana amayeri.Mubikorwa byubuvuzi, guta umutwe byuzuye birangwa no kutibuka neza, apasiya, apasiya, gutakaza kumenyekana, kubangamira ubuhanga bwo kubona no gutandukanya umwanya, imikorere mibi yubuyobozi, hamwe nimiterere nimpinduka zimyitwarire.Indwara ya etiologiya ntiramenyekana.Indwara yo guta igihe kitaragera bivuga abantu bagaragaza ibimenyetso mbere yimyaka 65;Abantu barwara umutwe nyuma yimyaka 65 bavugwa ko ari umusaza.Kuba indwara ya Alzheimer (AD) ikunze kuba ifitanye isano na protein- Amyloide proteine ​​(A β） Kwiyongera hamwe na Tau protein byinjira, kandi ubushakashatsi bwinshi bugenda bwerekana urutonde rwa neuroinflammation nkimwe mubintu bigira uruhare mu kubaho kwa AD.
Ijambo: Indwara ya Alzheimer ni iki?Reba kuri ubu bumenyi.Abantu Kumunsi Kumurongo.2023-09-20

Menya ko hari ubwoko bwa bagiteri zishobora kwinjira mumaraso yubwonko

Vuba aha, abashakashatsi bo mu Ishuri Rikuru ry’Ubuvuzi rya Baylor muri Amerika basohoye urupapuro rw’ubushakashatsi rwiswe: Toll nka reseptor 4 na CD11b byagaragajwe kuri microglia ihuza ihanagura rya Candida albicans cerebral mycose mu kinyamakuru Cell Reports.
Twabonye igihumyo cyitwa Candida albicans gishobora kwinjira mu bwonko binyuze mumaraso.Nkuko abantu benshi babivuga, "Gukubita ukuguru kumugaye birashobora gutera indwara ya Alzheimer nkimpinduka."Muri ubu bushakashatsi, twongeye kwerekana uburyo bwa molekuline Candida albicans icamo inzitizi y'amaraso n'ubwonko yinjira mu bwonko, biganisha ku ndwara ya Alzheimer nk'impinduka.

Nigute Candida albicans yinjira mubwonko?Dogiteri Yifan Wu, impuguke mu by'abana b'inzobere mu kuvura indwara z'ubuvuzi ukora kuri Corry yagize ati: "Twabonye ko Candida albicans itanga umusemburo witwa protease rwihishwa (Saps), uhungabanya inzitizi y'amaraso n'ubwonko, bigatuma ibihumyo byinjira mu bwonko bikangiza." Laboratoire.

Candida albicans

Candida albicans (izina ry'ubumenyi: Candida albicans) ni umusemburo ushobora gutera kwandura amahirwe.Bikunze kuboneka mumuryango wa bagiteri yumubiri wigifu na urogenital.Abagera kuri 40% kugeza kuri 60% byabantu bakuze bafite ubuzima bwiza bafite Candida albicans mu kanwa kabo no mu gifu.Ubusanzwe Candida albicans ibana numubiri wumuntu, ariko irashobora gukura mugihe cyo kubura ubudahangarwa no gutera kandidiasis.Ni bagiteri ikunze kwibasira ubwoko bwa Candida

Nk’uko ubushakashatsi bwakozwe muri Cell Reports bubitangaza, ibihumyo tutakunze kwitaho cyane bishobora no kuba umwe mu nyirabayazana w'indwara ya Alzheimer.Abashakashatsi bo mu Ishuri ry’Ubuvuzi rya Baylor n’ibigo bifatanya bavumbuye binyuze mu cyitegererezo cy’inyamaswa uburyo Candida albicans yinjira mu bwonko n’uburyo ikora uburyo bubiri bwigenga mu ngirabuzimafatizo z’ubwonko buteza imbere ubwabwo (bukaba ari ingenzi cyane mu gusobanukirwa n’iterambere ry’indwara ya Alzheimer), kandi butanga umusaruro Protein Poroteyine ya Amyloide (A β） Peptide (proteine ​​zifite ubumara bwa poroteyine ya amyloide) ifatwa nk’intandaro y’iterambere ry’indwara ya Alzheimer.

Dr. David Corry yavuze.David Corry ni Umuyobozi w’ubuvuzi muri Fondasiyo ya Fulbright akaba n'umwarimu w’indwara z’indwara, ubudahangarwa, n’ubuvuzi muri kaminuza ya Baylor.Ni umunyamuryango wa Baylor L. Duncan Comprehensive Cancer Centre.Muri 2019, twasanze Candida albicans yinjiye mubwonko kandi itanga impinduka zisa n'indwara ya Alzheimer.Umuriro uterwa na Candida albicans akenshi uherekeza
A β Impamvu yo gukora amyloide nka peptide nuko Sap ishobora hydrolyze amyloide precursor proteins (APPs).

Nyamara, iyi peptide ikurura kandi ingirabuzimafatizo z'umubiri - microglia, zikaba ari ingenzi cyane cyane nyuma yo gukuraho Candida albicans ubwonko ubwabwo.Mubyongeyeho, uburozi Candidalysin bwakozwe na Candida albicans ikora microglia ikoresheje indi nzira.Niba iyi nzira ihungabanye, ibihumyo mubwonko ntibishobora kuvaho.
Abashakashatsi berekana ko iki gikorwa gishobora kuba urujijo rukomeye rwo gusobanukirwa n’indwara ya Alzheimer.Ubushakashatsi bwibanze bwagaragaje ko poroteyine zo mu bwonko zigira uruhare mu gusenya porogaramu kandi zikagira uruhare kuri A β Kwiyegeranya byashizeho urufatiro.Noneho noneho birashobora kwemezwa ko protease exogenous protease iva mu bihumyo nayo ishobora gutera A β Peptide nkumusaruro.
Abashakashatsi berekana ko hakenewe isuzumabumenyi ryerekana uruhare rwa Candida albicans mu iterambere ry’indwara ya Alzheimer mu gihe kiri imbere, ibyo bikaba bishobora no gutuma habaho ingamba zo kuvura AD.
Ibikoresho bifatika:
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[2] Ubwonko bukora ubwonko bukora Indwara ya Alzheimer nkimpinduka, vuga ubushakashatsi bushya Yakuwe ku ya 17 Ukwakira 2023 kuva https://medicalxpress.com/amakuru/2023-10-ubwonko